WordReference Random House Unabridged Dictionary of American English © 2026
mac•ro•mu•ta•tion
(mak′rō myo̅o̅ tā′shən),USA pronunciation n. [Genetics.]
- Geneticsa mutation that has a profound effect on the resulting organism, as a change in a regulatory gene that controls the expression of many structural genes.
- macro- + mutation
'macromutation' also found in these entries (note: many are not synonyms or translations):