WordReference English-Spanish Dictionary © 2025:

Principal Translations
InglésEspañol
Oh brother! interj US, slang (expressing exasperation) (ES, coloquial)¡o, tío! interj
  (AR, coloquial)¡dale hermano! loc interj
 Esta oración no es una traducción de la original. ¡Jo, tía! Me tienes harta.
 Esta oración no es una traducción de la original. ¡Dale hermana! Me tenés harta.
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See Google Translate's machine translation of 'Oh brother!'.

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